反应详情

6.0 gm (0.02 mol) of 5-(3-chloro-propionyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one and 10 gm (0.11 mol) of morpholine were refluxed in 200 ml of isopropanol for 2 hours. The solvent was distilled off, the residue was dissolved in methylene chloride, and the solution was washed with water. After distilling off the solvent, the residue was recrystallized from isopropanol.

1. distillationThe solvent was distilled off
2. dissolutionthe residue was dissolved in methylene chloride
3. washthe solution was washed with water
4. distillationAfter distilling off the solvent
5. customthe residue was recrystallized from isopropanol