Ammonia → HCID 12920006, compound

HRID 354806Notes

Reaction equation

HRID 354806 reaction equation
[NH3:1].[Cl:2][C:3]1[N:12]=[C:11](Cl)[C:10]2[C:5](=[C:6]([O:17][CH3:18])[C:7]([O:15][CH3:16])=[C:8]([Cl:14])[CH:9]=2)[N:4]=1>O1CCCC1>[Cl:2][C:3]1[N:12]=[C:11]([NH2:1])[C:10]2[C:5](=[C:6]([O:17][CH3:18])[C:7]([O:15][CH3:16])=[C:8]([Cl:14])[CH:9]=2)[N:4]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 12920004HCID 12920004, compound

Product 1

HCID 12920006HCID 12920006, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Ammonia was passed into a solution of 2,4,6-trichloro-7,8-dimethoxyquinazoline (31.4 g., 0.107 mole) in 650 ml. dry tetrahydrofuran for one hour at room temperature. After stirring for an additional hour, the suspension was concentrated in vacuo and filtered. The solid was resuspended in water, filtered, washed with water and methanol. Recrystallization from dimethylformamide/water yielded 23.7 g. (81%) of the desired product, M.P., 360° C.

Workup

  1. concentrationthe suspension was concentrated in vacuo
  2. filtrationfiltered
  3. filtrationfiltered
  4. washwashed with water and methanol
  5. customRecrystallization from dimethylformamide/water
  6. customyielded 23.7 g

Sources & evidence

ORD record
ord-2f3affeb894d4245ae8669bae7e7d06f
Source dataset
uspto-grants-1983_03
Patent number
US04377581

Reaction notes

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