Ammonia → 2,6-Dichloro-7-methoxyquinazolin-4-amine

HRID 354807Notes

Reaction equation

[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][C:6]([O:14][CH3:15])=[C:7]([Cl:13])[CH:8]=2)[N:3]=1.[NH3:16]>>[Cl:1][C:2]1[N:11]=[C:10]([NH2:16])[C:9]2[C:4](=[CH:5][C:6]([O:14][CH3:15])=[C:7]([Cl:13])[CH:8]=2)[N:3]=1

Participants

Reactant 2

HCID 222Ammonia

HCID 129200052,4,6-Trichloro-7-methoxyquinazoline

Product 1

HCID 129200072,6-Dichloro-7-methoxyquinazolin-4-amineYield 58%

Procedure

Reaction of 2,4,6-trichloro-7-methoxyquinazoline with ammonia as described above afforded 2,6-dichloro-4-amino-7-methoxyquinazoline as a white solid, M.P., 300° C. in 58% yield.

Sources & evidence

ORD record: ord-e786d94270b54d9cbdcca4a573edef13
Source dataset: uspto-grants-1983_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04377581

Reaction notes

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