4-Hydroxypyrrolidine → HCID 20506397, compound

HRID 354817Notes

Reaction equation

HRID 354817 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[C:7]([O:15][CH3:16])[C:8]([O:13][CH3:14])=[C:9]([Cl:12])[CH:10]=2)[N:5]=[C:4](Cl)[N:3]=1.[NH:18]1[CH2:22][CH2:21][CH:20]([OH:23])[CH2:19]1>C(O)CC(C)C>[ClH:12].[OH:23][CH:20]1[CH2:21][CH2:22][N:18]([C:4]2[N:3]=[C:2]([NH2:1])[C:11]3[C:6](=[C:7]([O:15][CH3:16])[C:8]([O:13][CH3:14])=[C:9]([Cl:12])[CH:10]=3)[N:5]=2)[CH2:19]1

Participants

4

Reactant 2

HCID 982104-HydroxypyrrolidineHCID 12920006HCID 12920006, compound

Product 1

HCID 20506397HCID 20506397, compound

Reagents, catalysts & solvents 1

HCID 31260Isoamyl AlcoholSolvent

Procedure

A mixture of 4-amino-2,6-dichloro-7,8-dimethoxyquinazoline (5.48 g., 0.020 mole) and 3-pyrrolidinol (2.18 g., 0.025 mole) in 150 ml. of isoamyl alcohol is heated at reflux for five hours then cooled in ice. The precipitated product is collected by filtration and purified by recrystallization to obtain the title compound.

Workup

  1. temperatureat reflux for five hours
  2. temperaturethen cooled in ice
  3. filtrationThe precipitated product is collected by filtration
  4. custompurified by recrystallization

Sources & evidence

ORD record
ord-9cf45c9b3e0b4be6a0f8e3a39a7ffcec
Source dataset
uspto-grants-1983_03
Patent number
US04377581

Reaction notes

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