Ammonia → HCID 53720619, compound

HRID 354820Notes

Reaction equation

HRID 354820 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([O:14][CH3:15])[C:11]=1[O:12][CH3:13])[N:8]=[C:7]([S:16][CH3:17])[N:6]=[C:5]2SC.[NH3:20]>O1CCCC1>[CH3:17][S:16][C:7]1[N:6]=[C:5]([NH2:20])[C:4]2[C:9](=[C:10]([O:14][CH3:15])[C:11]([O:12][CH3:13])=[C:2]([Cl:1])[CH:3]=2)[N:8]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 54304804HCID 54304804, compound

Product 1

HCID 53720619HCID 53720619, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To 0.1 mole of 6-chloro-2,4-dimethylmercapto-7,8-dimethoxyquinazoline in 200 ml. of tetrahydrofuran is added a solution of 0.1 mole of anhydrous ammonia in tetrahydrofuran. The mixture is stirred at room temperature for 18 hours and the precipitate which forms is collected and recrystallized from dimethylformamide/water to yield 2-methylmercapto-4-amino-6-chloro-7,8-dimethoxyquinazoline.

Workup

  1. customthe precipitate which forms is collected
  2. customrecrystallized from dimethylformamide/water

Sources & evidence

ORD record
ord-a97923e0a13a405e80a42f29a493cb59
Source dataset
uspto-grants-1983_03
Patent number
US04377581

Reaction notes

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