HCID 20506402, compound → HCID 20506389, compound

HRID 354821Notes

Reaction equation

HRID 354821 reaction equation
CS[C:3]1[N:12]=[C:11]([NH2:13])[C:10]2[C:5](=[C:6]([O:17][CH3:18])[C:7]([O:15][CH3:16])=[C:8]([Cl:14])[CH:9]=2)[N:4]=1.[CH2:19]([CH:25]1[CH2:29][CH2:28][NH:27][CH2:26]1)[CH2:20][CH2:21][CH2:22][CH2:23][CH3:24]>C(O)CC(C)C>[CH2:19]([CH:25]1[CH2:29][CH2:28][N:27]([C:3]2[N:12]=[C:11]([NH2:13])[C:10]3[C:5](=[C:6]([O:17][CH3:18])[C:7]([O:15][CH3:16])=[C:8]([Cl:14])[CH:9]=3)[N:4]=2)[CH2:26]1)[CH2:20][CH2:21][CH2:22][CH2:23][CH3:24]

Participants

4

Reactant 2

HCID 20506402HCID 20506402, compoundHCID 53720619HCID 53720619, compound

Product 1

HCID 20506389HCID 20506389, compound

Reagents, catalysts & solvents 1

HCID 31260Isoamyl AlcoholSolvent

Procedure

A mixture of 0.1 mole of 2-methylmercapto-4-amino-6-chloro-7,8-dimethoxyquinazoline and 0.12 mole of 3-n-hexylpyrrolidine in isoamyl alcohol is heated at reflux for 16 hours, cooled, washed with water and the organic phase is concentrated in vacuo. Hexane is slowly added to the residue and the solid title compound is collected and purified, if desired by silica gel column chromatography.

Workup

  1. temperatureis heated
  2. temperatureat reflux for 16 hours
  3. temperaturecooled
  4. washwashed with water
  5. concentrationthe organic phase is concentrated in vacuo
  6. additionHexane is slowly added to the residue
  7. customthe solid title compound is collected
  8. custompurified

Sources & evidence

ORD record
ord-dea54653d3d243b79e7d6ca9787b9004
Source dataset
uspto-grants-1983_03
Patent number
US04377581

Reaction notes

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