Ethanol → HCID 20506418, compound

HRID 354823Notes

Reaction equation

HRID 354823 reaction equation
[CH2:1]([OH:3])[CH3:2].[O-]CC.[Na+].C1(O)C=CC=CC=1.[Cl:15][C:16]1[N:25]=[C:24](Cl)[C:23]2[C:18](=[C:19]([O:30][CH3:31])[C:20]([O:28][CH3:29])=[C:21]([Cl:27])[CH:22]=2)[N:17]=1>>[Cl:15][C:16]1[N:25]=[C:24]([O:3][CH2:1][CH3:2])[C:23]2[C:18](=[C:19]([O:30][CH3:31])[C:20]([O:28][CH3:29])=[C:21]([Cl:27])[CH:22]=2)[N:17]=1

Participants

5

Reactant 4

HCID 702EthanolHCID 996PhenolHCID 2723922Sodium ethoxideHCID 12920004HCID 12920004, compound

Product 1

HCID 20506418HCID 20506418, compound

Procedure

To 5 liters of ethanol containing 0.2 mole of sodium ethoxide is added slowly with stirring 0.1 mole each of phenol and 2,4,6-trichloro-7,8-dimethoxyquinazoline. The mixture is heated to boiling then allowed to stand at room temperature overnight, poured into ice-water, stirred 15 minutes and the precipitate collected by filtration. The cake is washed with water, then cold ethanol, dried and recrystallized from ethanol/hexane to obtain 2,6-dichloro-7,8-dimethoxy-4-ethoxyquinazoline.

Workup

  1. temperatureThe mixture is heated
  2. filtrationthe precipitate collected by filtration
  3. washThe cake is washed with water
  4. dry with materialcold ethanol, dried
  5. customrecrystallized from ethanol/hexane

Sources & evidence

ORD record
ord-4f098a3aa45d4c569a16b76857793448
Source dataset
uspto-grants-1983_03
Patent number
US04377581

Reaction notes

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