Morpholine → 2-(Morpholin-4-yl)-4-amino-7,8-dimethoxyquinazoline hydrochloride

HRID 354824Notes

Reaction equation

HRID 354824 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[C:7]([O:14][CH3:15])[C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[N:5]=[C:4]([Cl:16])[N:3]=1.[NH:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1>CC(CC)=O>[ClH:16].[N:17]1([C:4]2[N:3]=[C:2]([NH2:1])[C:11]3[C:6](=[C:7]([O:14][CH3:15])[C:8]([O:12][CH3:13])=[CH:9][CH:10]=3)[N:5]=2)[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 129200082-Chloro-4-amino-7,8-dimethoxyquinazoline

Product 1

HCID 205063952-(Morpholin-4-yl)-4-amino-7,8-dimethoxyquinazoline hydrochloride

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

To 500 ml. of methylethylketone is added 0.1 mole of 4-amino-2-chloro-7,8-dimethoxyquinazoline and 0.12 mole of morpholine and the mixture is refluxed overnight. After cooling in ice-water the solid precipitated is collected by filtration, washed with ether and air dried to obtain the title compound.

Workup

  1. temperaturethe mixture is refluxed overnight
  2. customprecipitated
  3. filtrationis collected by filtration
  4. washwashed with ether and air
  5. customdried

Sources & evidence

ORD record
ord-ad4443fbe555441f8508b74f7dd1ab9d
Source dataset
uspto-grants-1983_03
Patent number
US04377581

Reaction notes

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