HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 2-(Morpholin-4-yl)-4-amino-7,8-dimethoxyquinazoline hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 2-Chloro-4-amino-7,8-dimethoxyquinazoline | HCID 12920008 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 2-(Morpholin-4-yl)-4-amino-7,8-dimethoxyquinazoline hydrochloride | HCID 20506395 | — |
Reaction Steps
To 500 ml. of methylethylketone is added 0.1 mole of 4-amino-2-chloro-7,8-dimethoxyquinazoline and 0.12 mole of morpholine and the mixture is refluxed overnight. After cooling in ice-water the solid precipitated is collected by filtration, washed with ether and air dried to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04377581 |
| Source dataset | uspto-grants-1983_03 |
| ORD ID | ord-ad4443fbe555441f8508b74f7dd1ab9d |
| Source note | uspto-grants-1983_03 |