反应详情

温度

220 °C

A mixture of o-aminobenzonitrile (22.58 g) and formamide (96 ml) was refluxed for 2 hours at 220° C. After the resultant mixture was cooled to ambient temperature, precipitated crystals were separated by filtration, washed twice with a small volume of water and dried under reduced pressure to give crystalline 4-aminoquinazoline (17.0 g).

1. customprecipitated crystals
2. customwere separated by filtration
3. washwashed twice with a small volume of water
4. customdried under reduced pressure