Methanol → HCID 13060458, compound

HRID 354852Notes

Reaction equation

HRID 354852 reaction equation
[Na].[NH2:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([CH2:13][CH3:14])[CH:11]=2)[N:6]=[C:5](Cl)[N:4]=1.[OH2:16].[CH3:17]O>>[NH2:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([CH2:13][CH3:14])[CH:11]=2)[N:6]=[C:5]([O:16][CH3:17])[N:4]=1

Participants

5

Reactant 4

HCID 887MethanolHCID 962WaterHCID 5360545SodiumHCID 13060457HCID 13060457, compound

Product 1

HCID 13060458HCID 13060458, compound

Conditions

Temperature
60 °C

Procedure

To a solution of sodium metal (1.19 g) in methanol (270 ml) was added 4-amino-2-chloro-6-ethylquinazoline (9.01 g). The reaction mixture was heated under reflux for 7 hours and heated for 38 hours at 60° C. The resultant mixture was concentrated under reduced pressure to give a residue, to which was added water under warming with stirring. The precipitates were separated by filtration and dried under reduced pressure to give crystalline 4-amino-6-ethyl-2-methoxyquinazoline (6.77 g).

Workup

  1. temperatureThe reaction mixture was heated
  2. temperatureunder reflux for 7 hours
  3. concentrationThe resultant mixture was concentrated under reduced pressure
  4. customto give a residue
  5. temperatureunder warming
  6. customThe precipitates were separated by filtration
  7. customdried under reduced pressure

Sources & evidence

ORD record
ord-da2c8b5aa80c42cba61e1892969c442f
Source dataset
uspto-grants-1983_03
Patent number
US04377580

Reaction notes

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