Water → HCID 13060550, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 4-oxo-4H-pyrimido[1,2-c]-quinazoline-3-carboxylate (6.3 g) and lithium iodide (15.8 g) in N,N-dimethylformamide (100 ml) was stirred for 2 hours and a half at 150° C. and then cooled to ambient temperature. To the reaction mixture was added water separated by filtration, washed with water (600 ml) and dried to give crystalline 4-oxo-4H-pyrimido[1,2-c]quinazoline-3-carboxylic acid (0.9 g).

Provenance & Evidence