Water → HCID 13060550, compound

HRID 354875Notes

Reaction equation

HRID 354875 reaction equation
[O:1]=[C:2]1[N:7]2[CH:8]=[N:9][C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=3[C:6]2=[N:5][CH:4]=[C:3]1[C:16]([O:18]C)=[O:17].[I-].[Li+].O>CN(C)C=O>[O:1]=[C:2]1[N:7]2[CH:8]=[N:9][C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=3[C:6]2=[N:5][CH:4]=[C:3]1[C:16]([OH:18])=[O:17]

Participants

5

Reactant 3

HCID 962WaterHCID 66321Lithium iodideHCID 13060521HCID 13060521, compound

Product 1

HCID 13060550HCID 13060550, compoundYield 15.1%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
150 °C

Procedure

A mixture of methyl 4-oxo-4H-pyrimido[1,2-c]-quinazoline-3-carboxylate (6.3 g) and lithium iodide (15.8 g) in N,N-dimethylformamide (100 ml) was stirred for 2 hours and a half at 150° C. and then cooled to ambient temperature. To the reaction mixture was added water separated by filtration, washed with water (600 ml) and dried to give crystalline 4-oxo-4H-pyrimido[1,2-c]quinazoline-3-carboxylic acid (0.9 g).

Workup

  1. customseparated by filtration
  2. washwashed with water (600 ml)
  3. customdried

Sources & evidence

ORD record
ord-b72ea87edd224b5eac40763a4bda7eb9
Source dataset
uspto-grants-1983_03
Patent number
US04377580

Reaction notes

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