Methoxyacetyl chloride → HCID 13209079, compound

HRID 354907Notes

Reaction equation

HRID 354907 reaction equation
[CH3:1][O:2][CH2:3][C:4](Cl)=[O:5].[CH3:7][O:8][C:9]([CH:11]([NH:13][C:14]1[C:19]([CH3:20])=[CH:18][CH:17]=[C:16]([N+:21]([O-:23])=[O:22])[C:15]=1[CH3:24])[CH3:12])=[O:10]>>[CH3:7][O:8][C:9]([CH:11]([N:13]([C:4](=[O:5])[CH2:3][O:2][CH3:1])[C:14]1[C:19]([CH3:20])=[CH:18][CH:17]=[C:16]([N+:21]([O-:23])=[O:22])[C:15]=1[CH3:24])[CH3:12])=[O:10]

Participants

3

Reactant 2

HCID 96623Methoxyacetyl chlorideHCID 14157301HCID 14157301, compound

Product 1

HCID 13209079HCID 13209079, compound

Procedure

15.2 g of methoxyacetyl chloride are added dropwise at room temperature to 32 g of N-(1'methoxycarbonylethyl)-2,6-dimethyl-3-nitroaniline. After the weakly exothermic reaction has subsided, the reaction solution is stirred for 20 hours at room temperature. The solvent is then removed and the dark red oily residue is distilled in a high vacuum. Compound 28 distills at a temperature of 170°-174° C. and a pressure of 0.07 mbar as a pale yellow oil.

Workup

  1. customAfter the weakly exothermic reaction
  2. customThe solvent is then removed
  3. distillationthe dark red oily residue is distilled in a high vacuum
  4. distillationCompound 28 distills at a temperature of 170°-174° C.

Sources & evidence

ORD record
ord-81184351643c4f218a6de3830b53bef7
Source dataset
uspto-grants-1983_03
Patent number
US04377587

Reaction notes

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