HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-Methyl-4-[(trifluoromethanesulfonyl)amino]benzene-1-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 4-[(Trifluoromethanesulfonyl)amino]benzene-1-sulfonyl chloride | HCID 13537883 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-Methyl-4-[(trifluoromethanesulfonyl)amino]benzene-1-sulfonamide | HCID 13422926 | 44.1% |
Reaction Steps
A mixture of a 40% aqueous solution of methylamine (0.7 g), 4-(trifluoromethanesulfonamido)benzenesulfonyl chloride (1.5 g) and water (20 ml) was allowed to stand overnight and made acidic with hydrochloric acid to pecipitate crystals, which were then recrystallized from a mixture of water and ethanol to give 0.65 g of N-methyl-4-(trifluoromethanesulfonamido)benzenesulfonamide (Compound No. 2). M.P., 156°-157° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04767446 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-d857f4b40ccf4f28a1571e5e90d552b3 |
| Source note | uspto-grants-1988_08 |