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HRID35494

反应详情

EQUATION

反应方程式

HRID 35494 的结构方程式

REACTANTS

反应物

3
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CN
HCID6329

Methylamine

CH5N

结构：O=S(=O)(Cl)c1ccc(NS(=O)(=O)C(F)(F)F)cc1
HCID13537883

4-[(Trifluoromethanesulfonyl)amino]benzene-1-sulfonyl chloride

C7H5ClF3NO4S2

PRODUCTS

生成物

1
结构：CNS(=O)(=O)c1ccc(NS(=O)(=O)C(F)(F)F)cc1
HCID13422926

N-Methyl-4-[(trifluoromethanesulfonyl)amino]benzene-1-sulfonamide

C8H9F3N2O4S2

收率 44.1%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

A mixture of a 40% aqueous solution of methylamine (0.7 g), 4-(trifluoromethanesulfonamido)benzenesulfonyl chloride (1.5 g) and water (20 ml) was allowed to stand overnight and made acidic with hydrochloric acid to pecipitate crystals, which were then recrystallized from a mixture of water and ethanol to give 0.65 g of N-methyl-4-(trifluoromethanesulfonamido)benzenesulfonamide (Compound No. 2). M.P., 156°-157° C.

WORKUP

后处理

  1. customwere then recrystallized from a mixture of water and ethanol