Hydrochloric Acid → HCID 12634859, compound

HRID 354971Notes

Reaction equation

HRID 354971 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]([C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=1)O.[ClH:18]>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]([Cl:18])[C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 20506318HCID 20506318, compound

Product 1

HCID 12634859HCID 12634859, compound

Procedure

A mixture of 22 parts of 2,4-dichloro-α-(4-fluorophenyl)benzenemethanol and 240 parts of hydrochloric acid solution 12 N is stirred for 40 hours at room temperature. The reaction mixture is poured onto ice-water and the product is extracted with trichloromethane. The extract is washed with water, dried, filtered and evaporated. The residue is distilled, yielding 13.2 parts of 2,4-dichloro-1-[chloro-(4-fluorophenyl)methyl]benzene; bp. 146° C. at 0.15 mm. pressure.

Workup

  1. additionThe reaction mixture is poured onto ice-water
  2. extractionthe product is extracted with trichloromethane
  3. washThe extract is washed with water
  4. customdried
  5. filtrationfiltered
  6. customevaporated
  7. distillationThe residue is distilled

Sources & evidence

ORD record
ord-1e56cfc6ce9c4c538e193df5c3d3bf46
Source dataset
uspto-grants-1983_03
Patent number
US04377578

Reaction notes

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