反应详情

2,4-Dimethyl-3-(trifluoromethanesulfonamido)benzenesulfonyl chloride (1.4 g) was added to tetrahydrofuran (20 ml) containing dimethylamine (0.6 g), and the resultant mixture was allowed to stand overnight at room temperature. The reaction mixture was concentrated, admixed with 5% hydrochloric acid and extracted with chloroform. The extract was washed with 5% hydrochloric acid and water in order, dried over anhydrous magnesium sulfate and concentrated to give an oily substance, which was purified by column chromatography with silica gel (150 ml) to give 1.0 g of N,N-dimethyl-2,4-dimethyl-3-(trifluoromethanesulfonamido)benzenesulfonamide (Compound No. 62) M.P., 70.5°-72° C.

1. concentrationThe reaction mixture was concentrated
2. extractionextracted with chloroform
3. washThe extract was washed with 5% hydrochloric acid and water in order
4. dry with materialdried over anhydrous magnesium sulfate
5. concentrationconcentrated
6. customto give an oily substance, which
7. customwas purified by column chromatography with silica gel (150 ml)