HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorzoxazone → 8-(5-Chloro-2-oxo-benzoxazolin-3-yl)-caprylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorzoxazone | HCID 2733 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Methyl 8-bromooctanoate | HCID 11107373 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 8-(5-Chloro-2-oxo-benzoxazolin-3-yl)-caprylic acid methyl ester | HCID 12961165 | — |
Reaction Steps
The product is produced as described in example 1 from 3 g. of NaH (80% suspension in mineral oil), 17 g. of 5-chloro-benzoxazolin-2-one (produced in usual manners by subjecting 2-amino-4-chloro-phenol-hydrochloride to reaction with phosgene), 200 cc. of DMF, 23.7 g. of 8-bromo-caprylic acid methyl ester and 3 g. of NaJ.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04377695 |
| Source dataset | uspto-grants-1983_03 |
| ORD ID | ord-1276cb9699e947f78b4dcbe8f2f4cf38 |
| Source note | uspto-grants-1983_03 |