HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Hydroxy benzimidazole → 8-(2-Oxobenzimidazolin-1-yl)-caprylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Hydroxy benzimidazole | HCID 11985 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Methyl 8-bromooctanoate | HCID 11107373 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 8-(2-Oxobenzimidazolin-1-yl)-caprylic acid methyl ester | HCID 12961171 | — |
Reaction Steps
The product is produced as described in example 1 from 2.8 g. of NaH (80% suspension in mineral oil), 25 g. of benzimidazolin-2-one, 180 cc. of DMF, 22.1 g. of 8-bromocaprylic acid methyl ester and 2.8 g. of NaJ. Eluant in chromatographic purification: chloroform/methanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04377695 |
| Source dataset | uspto-grants-1983_03 |
| ORD ID | ord-fefd9dabde024563a0c8f52b4a7146f2 |
| Source note | uspto-grants-1983_03 |