HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chlorobenzyl chloride → 8-[3-(2-Chlorobenzyl)-2-oxo-benzimidazolin-1-yl]-caprylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chlorobenzyl chloride | HCID 11906 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 8-(2-Oxobenzimidazolin-1-yl)-caprylic acid methyl ester | HCID 12961171 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 8-[3-(2-Chlorobenzyl)-2-oxo-benzimidazolin-1-yl]-caprylic acid methyl ester | HCID 54064410 | — |
Reaction Steps
The product is produced as described in example 1 from 0.72 g. of NaH (80% suspension in mineral oil), 7 g. of 8-(2-oxobenzimidazolin-1-yl)-caprylic acid methyl ester, 100 cc. of DMF, 3.9 g. of 2-chlorobenzylchloride and 0.72 g. of NaJ. Eluant of chromatographic purification: hexane/ethylacetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04377695 |
| Source dataset | uspto-grants-1983_03 |
| ORD ID | ord-c465750989714257a4b49b795dd72db4 |
| Source note | uspto-grants-1983_03 |