反应详情

温度

10 °C

3-Hydroxypiperidine (0.4 mole) is dissolved in 150 ml. of methylene chloride. The solution is cooled to 10° C. and acetic anhydride (0.46 mole) is added dropwise, maintaining the temperature under 20° C. The reaction mixture is allowed to come to room temperature, and is then refluxed for 2 hours. The methylene chloride is evaporated off, and the remaining liquid is distilled under high vacuum. A thick yellow oil is collected at 122°-126° C. (0.3 mm Hg).

1. temperaturemaintaining the temperature under 20° C
2. customto come to room temperature
3. temperatureis then refluxed for 2 hours
4. customThe methylene chloride is evaporated off
5. distillationthe remaining liquid is distilled under high vacuum
6. customA thick yellow oil is collected at 122°-126° C. (0.3 mm Hg)