Potassium Carbonate → 3-(Benzyloxy)piperidine

HRID 355125Notes

Reaction equation

HRID 355125 reaction equation
C([N:4]1[CH2:9][CH2:8][CH2:7][CH:6]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:5]1)(=O)C.[OH-].[Na+].C(=O)([O-])[O-].[K+].[K+]>O>[CH2:11]([O:10][CH:6]1[CH2:7][CH2:8][CH2:9][NH:4][CH2:5]1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 14798Sodium HydroxideHCID 205061191-Acetyl-3-benzyloxypiperidine

Product 1

HCID 199606043-(Benzyloxy)piperidine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1-Acetyl-3-benzyloxypiperidine (0.043 mole), sodium hydroxide (0.086 mole) and water (30 ml.) are combined and refluxed for 24 hours. The reaction mixture is saturated with potassium carbonate and extracted three times with ether. The ether is removed by evaporation and the yellow oil is distilled at 92°-94° C. (0.3 mm Hg.).

Workup

  1. temperaturerefluxed for 24 hours
  2. extractionextracted three times with ether
  3. customThe ether is removed by evaporation
  4. distillationthe yellow oil is distilled at 92°-94° C. (0.3 mm Hg.)

Sources & evidence

ORD record
ord-62c29e7729194ec8bec6da8df5c69f62
Source dataset
uspto-grants-1983_03
Patent number
US04377521

Reaction notes

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