Hydrochloric Acid → HCID 20505858, compound

HRID 355133Notes

Reaction equation

HRID 355133 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([S:11]([N:14]2[CH2:19][CH2:18][CH:17]([CH2:20]Cl)[CH2:16][CH2:15]2)(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[OH-].[Na+].Cl>O>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([S:11]([N:14]2[CH2:19][CH2:18][C:17](=[CH2:20])[CH2:16][CH2:15]2)(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 205059532-Chloro-5-(4-chloromethylpiperidinosulfonyl)benzoic Acid

Product 1

HCID 20505858HCID 20505858, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-Chloro-5-(4-chloromethylpiperidinosulfonyl)benzoic acid (0.5 g.) is dissolved in 10 ml. of 5 N sodium hydroxide and refluxed for one hour. 10 ml. of water is then added and the mixture is acidified with concentrated hydrochloric acid. The precipitated solid is chromatographed on a 10 g. silica gel column with a developing solvent system of 1:7 benzene:hexane containing 5% acetic acid. 2-Chloro-5-(4-methylenepiperidinosulfonyl)benzoic acid, m.p. 157°-160° C., is isolated from the first fraction.

Workup

  1. customThe precipitated solid is chromatographed on a 10 g

Sources & evidence

ORD record
ord-596fbfd0c3164d3b8165700932e3fedb
Source dataset
uspto-grants-1983_03
Patent number
US04377521

Reaction notes

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