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HRID355204

反应详情

EQUATION

反应方程式

HRID 355204 的结构方程式

REACTANTS

反应物

4
结构：c1c[nH]cn1
HCID795

Imidazole

C3H4N2

结构：O=S(=O)(O)O
HCID1118

Sulfuric acid

H2O4S

结构：CC(C)(C)[Si](C)(C)Cl
HCID28928

Chloro(1,1-dimethylethyl)dimethylsilane

C6H15ClSi

结构：O=C1C[C@@H]2[C@@H](CO)[C@H](OC(=O)c3ccccc3)C[C@@H]2O1
HCID2724454

4-(Hydroxymethyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl benzoate

C15H16O5

PRODUCTS

生成物

1
结构：CC(C)(C)[Si](C)(C)OC[C@@H]1[C@H]2CC(=O)O[C@H]2C[C@H]1OC(=O)c1ccccc1
HCID2724503

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

3
结构：CCOCC
溶剂HCID3283

Diethyl Ether

C4H10O

结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

结构：O.[Cl-].[Na+]
溶剂HCID57417360

Sodium chloride; water

ClH2NaO

CONDITIONS

反应条件

温度
20 °C

PROCEDURE

实验过程

A solution of 16.58 g of (1S,5R,6S,7R)-7-benzoyloxy-6-hydroxymethyl-2-oxabicyclo[3.3.0]octan-3-one in 18 ml of dimethylformamide is combined at 0° C. with 10.21 g of imidazole and 10.85 g of tert.-butyldimethylsilyl chloride. The mixture is stirred for 24 hours at 20° C., diluted with 1.5 l of ether, shaken in succession with 5% sulfuric acid and brine, dried over magnesium sulfate, and evaporated under vacuum. The residue is recrystallized from hexane.

WORKUP

后处理

  1. dry with materialdried over magnesium sulfate
  2. customevaporated under vacuum
  3. customThe residue is recrystallized from hexane