Diethyl Ether → HCID 20398478, compound

HRID 355206Notes

Reaction equation

HRID 355206 reaction equation
[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([C:6]([C:8]2[CH:20]=[CH:19][C:11]([O:12][C:13]([CH3:18])([CH3:17])[C:14](Cl)=[O:15])=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1.[Cl:23][C:24]1[CH:36]=[CH:35][C:27]([O:28][C:29]([CH3:34])([CH3:33])[C:30]([O-:32])=[O:31])=[CH:26][CH:25]=1.[CH2:37]([N:39](CC)CC)[CH3:38].CC[O:46][CH2:47][CH3:48]>>[Cl:23][C:24]1[CH:25]=[CH:26][C:27]([O:28][C:29]([CH3:34])([CH3:33])[C:30]([OH:32])=[O:31])=[CH:35][CH:36]=1.[Cl:23][C:24]1[CH:25]=[CH:26][C:27]([O:28][C:29]([CH3:34])([CH3:33])[C:30]([OH:32])=[O:31])=[CH:35][CH:36]=1.[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([C:6]([C:8]2[CH:20]=[CH:19][C:11]([O:12][C:13]([CH3:18])([CH3:17])[C:14]([N:39]([CH2:48][CH2:47][OH:46])[CH2:37][CH2:38][OH:28])=[O:15])=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1

Participants

5

Reactant 4

HCID 3283Diethyl Ether3×HCID 8471TriethylamineHCID 6918953HCID 6918953, compoundHCID 190258652-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoyl chloride

Product 1

HCID 20398478HCID 20398478, compound

Procedure

A solution of 1.948 g (5.8 millimoles) of 2-(4-(4-chlorobenzoyl)-phenoxy)-2-methyl propanoyl chloride in 10 ml of methylic ether was slowly added to a solution containing ether was slowly added to a solution containing 2.9 g (5.8 millimoles) of amino diethyl bis-2-(4-chlorophenoxy)-2-methylpropanoate (prepared according to French patent 2085634) and 0.83 ml (6 millimoles) of triethylamine in 30 ml of ethylic ether kept at 0° C.

Workup

  1. additionwas slowly added to a solution
  2. customkept at 0° C.

Sources & evidence

ORD record
ord-520db88d8c224773ae32ce2d0493c32d
Source dataset
uspto-grants-1983_03
Patent number
US04378373

Reaction notes

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