反应详情

1 3-Benzyloxy-2-methylpyrid-4-one (4 g) is dissolved in dry acetone (100 ml). Acetylbromide (3 g) and triethylamine (2.7 g) are added and the resulting mixture is mechanically stirred overnight. The mixture is then filtered and the filtrate is rotary evaporated to dryness. The residue is dissolved in methylene chloride and washed with dilute hydrochloric acid (pH 3.0), then twice with water, and is dried over Na2SO4 and rotary evaporated to yield a solid residue. Recrystallisation of this residue from an ethylacetate/hexane mixture gives 1-acetyl-3-benzyloxy-2-methylpyrid-4-one as an oil (3.1 g).

1. filtrationThe mixture is then filtered
2. customthe filtrate is rotary evaporated to dryness
3. dissolutionThe residue is dissolved in methylene chloride
4. washwashed with dilute hydrochloric acid (pH 3.0)
5. dry with materialtwice with water, and is dried over Na2SO4
6. customrotary evaporated
7. customto yield a solid residue
8. customRecrystallisation of this residue from an ethylacetate/hexane mixture