HCID 54238433, compound → HCID 18941941, compound

HRID 355330Notes

Reaction equation

HRID 355330 reaction equation
[C:1]([O:5][C:6]([NH:8][CH:9]([C:13]([CH3:23])([CH3:22])[CH:14]=[CH:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:10]([OH:12])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2]>[Pd].C(OCC)(=O)C>[C:1]([O:5][C:6]([NH:8][CH:9]([C:13]([CH3:23])([CH3:22])[CH2:14][CH2:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)[C:10]([OH:12])=[O:11])=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 54238433HCID 54238433, compound

Product 1

HCID 18941941HCID 18941941, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

The product of Example 18, Step 2, and 10% Pd/C are placed in a Parr bottle and mixed with ethyl acetate. The flask is purged with nitrogen and hydrogen and finally pressurized to 35 psi H2. The hydrogenation is run for 4 hours at room temperature. The catalyst is filtered off using a Celite pad and the filtrate is concentrated to give the pure product.

Workup

  1. customThe flask is purged with nitrogen and hydrogen
  2. filtrationThe catalyst is filtered off
  3. concentrationthe filtrate is concentrated
  4. customto give the pure product

Sources & evidence

ORD record
ord-415ea763d9d94ce69cb6351619fa7a20
Source dataset
uspto-grants-1998_11
Patent number
US05830869

Reaction notes

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