Isatin → 5H-[1,2,4]Triazino[5,6-b]indole-3-thiol

HRID 355366Notes

Reaction equation

HRID 355366 reaction equation
[NH2:1][NH:2][C:3]([NH2:5])=[S:4].[NH:6]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:9](=O)[C:7]1=O>>[N:1]1[NH:2][C:3](=[S:4])[N:5]=[C:7]2[C:9]=1[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=1[NH:6]2

Participants

3

Reactant 2

HCID 7054IsatinHCID 2723789Thiosemicarbazide

Product 1

HCID 1354038085H-[1,2,4]Triazino[5,6-b]indole-3-thiol

Procedure

In the general synthetic scheme, thiosemicarbazide is reacted with isatin to form 5H-1,2,4-triazino[5,6-b]indole-3(2H)-thione. This product is alkylated with an appropriate halo-derivative to provide the sulfur-substituent desired in the final product. ##STR3##

Sources & evidence

ORD record
ord-10fef698bd424a28a4719f4315506c4d
Source dataset
uspto-grants-1998_11
Patent number
US05830894

Reaction notes

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