Water → HCID 10035573, compound

HRID 355387Notes

Reaction equation

HRID 355387 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[NH:12]1[CH:16]=[N:15][CH:14]=[N:13]1.Cl.N1C=NC=N1.O>CN(C)C=O>[N:12]1([C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]=[CH:4][CH:3]=2)[CH:16]=[N:15][CH:14]=[N:13]1

Participants

6

Reactant 4

HCID 962WaterHCID 92571H-1,2,4-TriazoleHCID 691404-ChloroquinolineHCID 12217072HCID 12217072, compound

Product 1

HCID 10035573HCID 10035573, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

3.27 g of 4-chloro-quinoline, 1.38 g of 1H-1,2,4-triazole and 0.21 g of 1H-1,2,4-triazole hydrochloride are mixed in 10 ml of dimethyl-formamide for 1 hour at 80° C. The reaction mixture is added to 50 ml of water, neutralized with cc. aqueous ammonia, the precipitate is filtered, washed with water and recrystallized from 15 ml of ethanol. 2.47 g /63%/ of 4-(1H-1,2,4-triazole-1-yl)-quinoline (Substance 1) are obtained. M.p.:147°-149° C.

Workup

  1. filtrationaqueous ammonia, the precipitate is filtered
  2. washwashed with water
  3. customrecrystallized from 15 ml of ethanol

Sources & evidence

ORD record
ord-3684be33b87c4f029ca70b0b39cdd612
Source dataset
uspto-grants-1998_11
Patent number
US05830903

Reaction notes

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