HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3,5-Difluoro-2,4-dibenzyloxyphenyl)ethanol → 3',5'-Difluoro-2',4'-dibenzyloxyacetophenone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3,5-Difluoro-2,4-dibenzyloxyphenyl)ethanol | HCID 18942341 | — |
| Reactant | HCID 178418287 | HCID 178418287 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3',5'-Difluoro-2',4'-dibenzyloxyacetophenone | HCID 18942328 | — |
Reaction Steps
A 1.0M solution of Compound 24 in CH2Cl2 is added to a suspension of pyridinium chlorochromate (4.0 eq) in CH2Cl2 at 20° C. with stirring. The reaction is stirred for 24 hours and filtered through a pad of diatomaceous earth. The filtrate is concentrated in vacuo and then purified by silica gel column chromatography (eluted with Hex/EtOAc) to yield Compound 25.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05830912 |
| Source dataset | uspto-grants-1998_11 |
| ORD ID | ord-3f2121154c9e40cb9e0bd3c58c5a89e7 |
| Source note | uspto-grants-1998_11 |