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HRID355500

反应详情

EQUATION

反应方程式

HRID 355500 的结构方程式

REACTANTS

反应物

2
结构：CC1CO1
HCID6378

(+/-)-1,2-Propylene oxide

C3H6O

结构：OC[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](O)[C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@@H](O[C@H]5[C@H](O)[C@@H](O)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@@H](O[C@H]7[C@H](O)[C@@H](O)[C@@H](O[C@H]8[C@H](O)[C@@H](O)[C@@H](O[C@H]1[C@H](O)[C@H]2O)O[C@@H]8CO)O[C@@H]7CO)O[C@@H]6CO)O[C@@H]5CO)O[C@@H]4CO)O[C@@H]3CO
HCID444041

beta-Cyclodextrin

C42H70O35

PRODUCTS

生成物

1
结构：CC(O)COC[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](O)[C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@@H](O[C@H]5[C@H](O)[C@@H](O)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@@H](O[C@H]7[C@H](O)[C@@H](O)[C@@H](O[C@H]8[C@H](O)[C@@H](O)[C@@H](O[C@H]1[C@H](O)[C@H]2O)O[C@@H]8COCC(C)O)O[C@@H]7COCC(C)O)O[C@@H]6COCC(C)O)O[C@@H]5COCC(C)O)O[C@@H]4COCC(C)O)O[C@@H]3COCC(C)O
HCID14049689

6A,6B,6C,6D,6E,6F,6G-Heptakis-O-(2-hydroxypropyl)-β-cyclodextrinr

C63H112O42

收率 90%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：[Na+].[OH-]
溶剂HCID14798

Sodium Hydroxide

HNaO

PROCEDURE

实验过程

In HU 202889, β-cyclodextrin (β-CD) is reacted with propylene oxide in aqueous sodium hydroxide solution to give hydroxypropyl-β-cyclodextrin. The resulting sodium chloride and the propylene glycol are removed by ion exchange and precipitation of the hydroxypropylated β-cyclodextrin in large amounts of acetone, filtration, taking up the filter cake in water, distillation and, finally, spray-drying. The yield is around 90%, and the salt and propylene glycol content is 0.1%.