5-amino-1-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)imidazole-4-carboxylic acid → HCID 178516781, compound

Participants

Reaction Steps

Another method also known for the synthesis of coformycin comprises preparing and using 5-amino-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)imidazole-4-carboxylic acid as a starting material which is processed by multi-stage reactions to produce 3-(β-D-ribofuranosyl)-6,7-dihydroimidazo[4,5-d][1,3]diazepin-8(3H)-one as an intermediate, followed by reducing the intermediate (see H. J. Thomas et al., "Nucleosides & Nucleotides", 5, No. 4, pp. 431-439, 1986).

Provenance & Evidence