HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → Dicyclohexylcarbodiimide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | tert-Butanol | HCID 6386 | — |
| Reactant | 3-(4-Cyano 3-trifluoromethyl-phenyl) 5,5-dimethyl 2,4-dioxo 1-imidazolidine butanoic acid | HCID 22116971 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Dicyclohexylcarbodiimide | HCID 10868 | — |
Reaction Steps
By carrying out the esterification of the product of Example 62, with terbutanol in the presence of dicyclohexylcarbodiimide and 4-dimethylamino-pyridine as in Example 60, the expected product melting at 96°-97° C. with a Rf=0.32 (eluant: methylene chloride--acetone (98-2)) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | USRE035956 |
| Source dataset | uspto-grants-1998_11 |
| ORD ID | ord-85716178ca5244ada30906882a0c511f |
| Source note | uspto-grants-1998_11 |