Dichloromethane → Dicyclohexylcarbodiimide

HRID 355590Notes

Reaction equation

HRID 355590 reaction equation
C([C:3]1[CH:8]=[CH:7][C:6]([N:9]2C(=O)C(C)(C)[N:11]([CH2:17][CH2:18][CH2:19][C:20](O)=O)[C:10]2=O)=[CH:5][C:4]=1C(F)(F)F)#N.[C:28](O)(C)(C)[CH3:29].C(Cl)Cl>CN(C)C1C=CN=CC=1.CC(C)=O>[CH:17]1([N:11]=[C:10]=[N:9][CH:6]2[CH2:5][CH2:4][CH2:3][CH2:8][CH2:7]2)[CH2:18][CH2:19][CH2:20][CH2:29][CH2:28]1

Participants

6

Reactant 3

HCID 6344DichloromethaneHCID 6386tert-ButanolHCID 221169713-(4-Cyano 3-trifluoromethyl-phenyl) 5,5-dimethyl 2,4-dioxo 1-imidazolidine butanoic acid

Product 1

HCID 10868Dicyclohexylcarbodiimide

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 180AcetoneSolvent

Procedure

By carrying out the esterification of the product of Example 62, with terbutanol in the presence of dicyclohexylcarbodiimide and 4-dimethylamino-pyridine as in Example 60, the expected product melting at 96°-97° C. with a Rf=0.32 (eluant: methylene chloride--acetone (98-2)) was obtained.

Sources & evidence

ORD record
ord-85716178ca5244ada30906882a0c511f
Source dataset
uspto-grants-1998_11
Patent number
USRE035956

Reaction notes

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