HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 86753305, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 3-Methyl-2-butanone | HCID 11251 | — |
| Reactant | 2-(1-Methylhydrazinyl)-6-(trifluoromethyl)pyridine | HCID 18940146 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 86753305 | HCID 86753305 | — |
Reaction Steps
A solution of 1-[6-trifluoromethylpyrid-2-yl]-1-methyl hydrazine (12.12 g; 0.069 mol), 3-methyl-2-butanone (5.96 g; 0.069 mol) and p-toluenesulphonic acid (0.13 g) in toluene (70 ml) was heated under reflux, with water removal (azeotrope), for 24 h. The solution was concentrated to yield an oil which was purified by flash-chromatography over silica (eluent: 20% diethyl ether in hexane) to yield 3-methyl-2-butanone 1-[6-trifluoromethylpyrid-2-yl]-1-methyl hydrazone as an orange oil (11.6 g; 71%). ##STR22##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05833885 |
| Source dataset | uspto-grants-1998_11 |
| ORD ID | ord-8b6adf5f3cb949f181dd36add82a8281 |
| Source note | uspto-grants-1998_11 |