反应详情

温度

90 °C

Imidazole (0.816 g, 0.01 mol), ethyl 4-fluorobenzoate (2 g, 0.01 mol) and anhydrous potassium carbonate (1.43 g, 0.011 mol) was dissolved in DMSO (30 ml) and heated to 90° C. for 18 h. The solution was poured into water (50 ml), extracted with ethyl acetate (50 ml), dried (sodium sulphate), filtered and evaporated to dryness under reduced pressure. The white solid was purified by flash column chromatography (silica, diethyl ether) to afford a white solid (1.22 g, 56%).

1. extractionextracted with ethyl acetate (50 ml)
2. dry with materialdried (sodium sulphate)
3. filtrationfiltered
4. customevaporated to dryness under reduced pressure
5. customThe white solid was purified by flash column chromatography (silica, diethyl ether)