反应详情

Methyl 4-(2-(benzyloxy)benzyloxy)benzoate (1.01 g, 1.91 mmol) was dissolved in THF (20 ml) and methanol (7 ml). The solution was treated with NaOH (1N, 6 ml). The reaction was heated at reflux for 3 hours and then concentrated at reduced pressure. The pH was adjusted to pH1 with concentrated HCl and the solid filtered, washed with water and dried to give the title compound as a white solid (0.9 g, 98%).

1. temperatureThe reaction was heated
2. temperatureat reflux for 3 hours
3. concentrationconcentrated at reduced pressure
4. filtrationthe solid filtered
5. washwashed with water
6. customdried