HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Phenylpiperidin-4-ol → 1-(3-(3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-9H-beta-carbolin-9-yl)-1-propyl)-4-phenylpiperidin-4-ol hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Phenylpiperidin-4-ol | HCID 96387 | — |
| Reactant | 9-(3-Chloro-1-propyl)-3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-9H-beta-carboline | HCID 18940727 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(3-(3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-9H-beta-carbolin-9-yl)-1-propyl)-4-phenylpiperidin-4-ol hydrochloride | HCID 18940724 | 12% |
Reaction Steps
The compound was synthesized by mixing (Compound 6) (0.76 g, 2.2 mmol), 4-phenylpiperidin-4-ol (0.48 g, 2.7 mmol), TEA (0.55 g, 5.4 mmol) in DMF, in the same manner as illusterated in example 3. The compound was isolated as the hydrochloride (0.15 g, 12%) as an yellow solid. M.p. 184°-185° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05834482 |
| Source dataset | uspto-grants-1998_11 |
| ORD ID | ord-356cb7e0151f4816a48f1aea82d4b2b1 |
| Source note | uspto-grants-1998_11 |