HRID355819

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID96387

4-Phenylpiperidin-4-ol

C11H15NO

结构：ClCCCn1c2ccccc2c2cc(-c3nc(C4CC4)no3)ncc21

HCID18940727

未命名化合物

PRODUCTS

生成物

结构：Cl.OC1(c2ccccc2)CCN(CCCn2c3ccccc3c3cc(-c4nc(C5CC5)no4)ncc32)CC1

HCID18940724

未命名化合物

收率 12%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

The compound was synthesized by mixing (Compound 6) (0.76 g, 2.2 mmol), 4-phenylpiperidin-4-ol (0.48 g, 2.7 mmol), TEA (0.55 g, 5.4 mmol) in DMF, in the same manner as illusterated in example 3. The compound was isolated as the hydrochloride (0.15 g, 12%) as an yellow solid. M.p. 184°-185° C.

WORKUP

后处理

customThe compound was synthesized

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-356cb7e0151f4816a48f1aea82d4b2b1
来源数据集: uspto-grants-1998_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05834482
来源说明: uspto-grants-1998_11

反应 SMILES

[Cl:1][CH2:2][CH2:3][CH2:4][N:5]1[C:17]2[CH:16]=[N:15][C:14]([C:18]3[O:22][N:21]=[C:20]([CH:23]4[CH2:25][CH2:24]4)[N:19]=3)=[CH:13][C:12]=2[C:11]2[C:6]1=[CH:7][CH:8]=[CH:9][CH:10]=2.[C:26]1([C:32]2([OH:38])[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]2)[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>CN(C=O)C>[ClH:1].[CH:23]1([C:20]2[N:19]=[C:18]([C:14]3[N:15]=[CH:16][C:17]4[N:5]([CH2:4][CH2:3][CH2:2][N:35]5[CH2:34][CH2:33][C:32]([C:26]6[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=6)([OH:38])[CH2:37][CH2:36]5)[C:6]5[C:11]([C:12]=4[CH:13]=3)=[CH:10][CH:9]=[CH:8][CH:7]=5)[O:22][N:21]=2)[CH2:25][CH2:24]1