反应详情

2-t-Butoxycarbonylmethoxyimino-4-ethyl-5-nitro-3-hexenamide (80 mg) was treated with trifluoroacetic acid (1 ml) at ambient temperature for 2 hours. Excess trifluoroacetic acid was distilled off under reduced pressure to give a residue which was purified by preparative thin layer chromatography, eluting with a mixture of benzene, dioxane and acetic acid (14:5:1) to give 2-carboxymethoxyimino-4-ethyl-5-nitro-3-hexenamide (32 mg).

1. distillationExcess trifluoroacetic acid was distilled off under reduced pressure
2. customto give a residue which
3. customwas purified by preparative thin layer chromatography
4. washeluting with a mixture of benzene, dioxane and acetic acid (14:5:1)