ethyl 6-nitro-9H-beta-carboline-3-carboxylate → HCID 603089, compound

HRID 355824Notes

Reaction equation

HRID 355824 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[C:16]([C:17]=2[CH:18]=1)=[CH:15][C:14]([N+:19]([O-])=O)=[CH:13][CH:12]=3)=[O:5])[CH3:2]>C(O)C.[Pd]>[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[C:16]([C:17]=2[CH:18]=1)=[CH:15][C:14]([NH2:19])=[CH:13][CH:12]=3)=[O:5])[CH3:2]

Participants

4

Reactant 1

HCID 13037332ethyl 6-nitro-9H-beta-carboline-3-carboxylate

Product 1

HCID 603089HCID 603089, compoundYield 79%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A suspension of Pd (10% on carbon, 1.0 g), and Compound 15 (8.0 g, 28 mmol) in anhydrous ethanol (300 mL) was hydrogenated (2280 mL) at 1 atm. The reaction mixture was filtered through a filter aid. The filtrate was concentrated in vacuo to give the title compound (5.62 g, 79%). M.p. 226°-228° C.

Workup

  1. filtrationThe reaction mixture was filtered through a filter aid
  2. concentrationThe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-08d03a02c79b4aae8ea03540d63662db
Source dataset
uspto-grants-1998_11
Patent number
US05834482

Reaction notes

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