反应详情

Hydroxylamine hydrochloride (69.5 mg) was added to a solution of 4-ethyl-2-hydroxyimino-5-nitro-3-hexenal (100 mg) in a mixture of chloroform (3 ml) and methanol (2 ml) with stirring at room temperature. The resulting mixture was stirred at the same temperature overnight and evaporated to dryness. The residue was washed successively with water, aqueous sodium bicarbonate solution and brine, and dried over magnesium sulfate. The solvent was distilled under reduced pressure to give a residue which was purified by preparative thin layer chromatography [solvent: methanol-chloroform (10:90)] to give 4-ethyl-2-hydroxyimino-5- nitro-3-hexenaldehyde oxime (65 mg).

1. stirringThe resulting mixture was stirred at the same temperature overnight
2. customevaporated to dryness
3. washThe residue was washed successively with water, aqueous sodium bicarbonate solution and brine
4. dry with materialdried over magnesium sulfate
5. distillationThe solvent was distilled under reduced pressure
6. customto give a residue which
7. customwas purified by preparative thin layer chromatography [solvent: methanol-chloroform (10:90)]