反应详情

温度

100 °C

N-(3-Hydroxybenzyl)piperidine (9.55 g) was heated with 6-bromohexanenitrile (10.2 g) and potassium carbonate (13.8 g) under reflux in acetone (150 ml) for 66 hours. The reaction mixture was cooled and filtered. The solvent was removed by evaporation and the residue was heated with stirring at 100° C. for one hour to remove unreacted 6-bromohexanenitrile and to yield 6-(3-piperidinomethylphenoxy)hexanenitrile as an oil.

1. temperatureThe reaction mixture was cooled
2. filtrationfiltered
3. customThe solvent was removed by evaporation
4. temperaturethe residue was heated
5. customto remove unreacted 6-bromohexanenitrile