Sodium Carbonate → HCID 22449418, compound

HRID 355949Notes

Reaction equation

HRID 355949 reaction equation
[C:1]([NH:4][CH:5]1[CH2:14][C:13]2[C:8](=[C:9]([NH:17]C(=O)C)[CH:10]=[CH:11][C:12]=2[O:15][CH3:16])[C:7](=[O:21])[CH2:6]1)(=[O:3])[CH3:2].C(=O)([O-])[O-].[Na+].[Na+]>Cl>[C:1]([NH:4][CH:5]1[CH2:14][C:13]2[C:8](=[C:9]([NH2:17])[CH:10]=[CH:11][C:12]=2[O:15][CH3:16])[C:7](=[O:21])[CH2:6]1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 10340Sodium CarbonateHCID 86750958HCID 86750958, compound

Product 1

HCID 22449418HCID 22449418, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
60 °C

Procedure

102 mg of the compound prepared in (4) above was charged into 20 ml of 3N hydrochloric acid aqueous solution, and the mixture was heated at 60° C. for 2 hours while stirring. After cooling to 0° C., the reaction mixture was neutralized with sodium carbonate and extracted with chloroform. The extract was dried over magnesium sulfate, and subjected to silica gel column chromatography using an chloroform-methanol (40:1) mixed solvent as an eluant to obtain fractions containing the target compound. The fractions were concentrated to produce 66 mg of the title compound.

Workup

  1. temperatureAfter cooling to 0° C.
  2. extractionextracted with chloroform
  3. dry with materialThe extract was dried over magnesium sulfate
  4. additionmixed solvent as an eluant
  5. customto obtain fractions
  6. additioncontaining the target compound
  7. concentrationThe fractions were concentrated

Sources & evidence

ORD record
ord-ccc4fa31d2b3428392e5c6a60ff176e2
Source dataset
uspto-grants-1998_11
Patent number
US05834476

Reaction notes

Loading…