3-(Chloromethyl)pyridine → HCID 18940845, compound

HRID 355982Notes

Reaction equation

HRID 355982 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7]([Mg]Br)=[CH:6]2.Cl[CH2:15][C:16]1[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:15][C:16]1[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 183583-(Chloromethyl)pyridineHCID 178488093HCID 178488093, compound

Product 1

HCID 18940845HCID 18940845, compound

Procedure

The above mentioned compound was prepared analogously to the procedure described in J. Het. Chem. 3, 67 (1966) from 5-methoxy-indolyl-magnesium bromide and 3-chloromethylpyridine. After purification by Flash Chromatography on silica gel using as eluent methylene chloride/methanol/ammonia (98:2:0,1), the desired compound was obtained.

Workup

  1. customwas prepared analogously to the procedure
  2. customAfter purification by Flash Chromatography on silica gel using as eluent methylene chloride/methanol/ammonia (98:2:0,1)

Sources & evidence

ORD record
ord-7cd41f2ba4a44347be66caba0f7dd3a8
Source dataset
uspto-grants-1998_11
Patent number
US05834493

Reaction notes

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