Methyl iodide → HCID 18940820, compound

HRID 355990Notes

Reaction equation

HRID 355990 reaction equation
[CH3:1][I:2].[CH3:3][O:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[C:8]2[CH2:14][C:15]1[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=1>CC(C)=O>[I-:2].[CH3:3][O:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[C:8]2[CH2:14][C:15]1[CH:16]=[N+:17]([CH3:1])[CH:18]=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 18940845HCID 18940845, compound

Product 1

HCID 18940820HCID 18940820, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Methyl iodide (10.4 ml; 0.167 mol) was added to a stirring mixture of compound of Description 1 [5-methoxy-3-(pyridin-3-ylmethyl)-1H-indole] (5.3 g; 0.022 mol) in acetone (150 ml). The reaction mixture was stirred at room temperature for 18 hours. The reaction mixture was concentrated under vacuum. The residual solid was washed with diethyl ether giving the desired compound (7.5 g).

Workup

  1. concentrationThe reaction mixture was concentrated under vacuum
  2. washThe residual solid was washed with diethyl ether giving the desired compound (7.5 g)

Sources & evidence

ORD record
ord-2831fc370dcc4329a78afc4ba562d9f8
Source dataset
uspto-grants-1998_11
Patent number
US05834493

Reaction notes

Loading…