反应详情

1-Acetyl-5-(N,N-dimethylamino)indoline (D12) (0.6 g, 2.94 mmol) in conc. HCl (0.6 ml) was heated over a steam bath for 45 min. The mixture was partitioned between sat aq. K2CO3 (50 ml) and CHCl3 (50 ml) the organic solution dried (Na2SO4), evaporated to dryness under reduced pressure and purified by column chromatography (SiO2, EtOAc/MeOH 5-10%) to afford the title compound (290 mg, 61%) which was used directly in Example 4.

1. customThe mixture was partitioned
2. dry with materialdried (Na2SO4)
3. customevaporated to dryness under reduced pressure
4. custompurified by column chromatography (SiO2, EtOAc/MeOH 5-10%)