反应详情

A solution of the above alcohol (2.05 g) in dry dichloromethane (60 ml) was treated with a solution of thionyl chloride (3.3 ml) in dry dichloromethane (10 ml) and heated under reflux for 2.5 hours. The product was evaporated in vacuo to produce an oil which was crystallised from dry tetrahydrofuran to give colourless crystals of 3-piperidinomethylbenzyl chloride hydrochloride (m.p. 156°-160° C.).

1. temperatureheated
2. temperatureunder reflux for 2.5 hours
3. customThe product was evaporated in vacuo
4. customto produce an oil which
5. customwas crystallised from dry tetrahydrofuran