HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 1-{[3-(Chloromethyl)phenyl]methyl}piperidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (3-((Piperidin-1-yl)methyl)phenyl)methanol | HCID 7164645 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-{[3-(Chloromethyl)phenyl]methyl}piperidine hydrochloride | HCID 21294512 | — |
Reaction Steps
A solution of the above alcohol (2.05 g) in dry dichloromethane (60 ml) was treated with a solution of thionyl chloride (3.3 ml) in dry dichloromethane (10 ml) and heated under reflux for 2.5 hours. The product was evaporated in vacuo to produce an oil which was crystallised from dry tetrahydrofuran to give colourless crystals of 3-piperidinomethylbenzyl chloride hydrochloride (m.p. 156°-160° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04767769 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-d1616e458ccd4cdc807717a4f709da66 |
| Source note | uspto-grants-1988_08 |